There are extra considerations for Stacked Silicon Interconnect (SSI) parts. The SSI parts are made of multiple Super Logic Regions (SLRs), joined by an interposer. The interposer connections are called Super Long Lines (SLLs). There is some delay penalty when crossing from one SLR to another.
Keep the SLRs in mind when structuring the design, generating a pinout, and floorplanning. Minimize SLL crossings by keeping logic cells of critical timing paths inside a single SLR.
The I/Os must be placed in the same SLR as the relevant I/O interface circuitry. You must also carefully consider clock placement when laying out logic for SSI parts.