For any trace, its characteristic impedance is dependent on its stackup geometry as well as the trace geometry. In the case of differential traces, the inductive and capacitive coupling between the tightly coupled pair also determines the characteristic impedance of the traces.
The impedance of a trace is determined by its inductive and capacitive coupling to nearby conductors. For example, these conductors can be planes, vias, pads, connectors, and other traces, including the other closely coupled trace in a differential pair. The substrate properties, conductor properties, flux linkage area, and distance to a nearby conductor determine the amount of coupling and hence, the contribution to the final impedance.
2D field solvers are necessary in resolving these complex interactions and contribute to the calculation of the final impedance of the trace. They are also a useful tool to verify existing trace geometries.
Wider traces create a larger cross-sectional area for current to flow and reduce resistive losses in high-speed interfaces. Use the widest traces that space constraints allow. Because trace width tolerances are expressed in absolute terms, a wider trace also minimizes the percentage variation of the manufactured trace, resulting in tighter impedance control along the length of the transmission line.
Sometimes, striplines are preferred over microstrips because the reference planes on both sides of the trace provide radiation shielding. Microstrips are shielded on only one side (by the reference plane) because they run on the top-most or bottom-most layers, leaving the other side exposed to the environment.
For best results, the use of a 2D or 3D field solver is recommended for verification.