In the IP integrator Block Design Canvas, you can debug both nets and interfaces. You can right-click an interface or net in the Block Design and select Debug as follows. This sets the Debug and MARK_DEBUG attributes to true. In addition, this also enables the Designer Assistance to run Connection Automation, where you can choose the net and/or interface to a System Interface ILA core, and also customize the various attributes of the debug core.
Figure 1. IP Integrator Mark Debug
To clear a net and/or interface of debug attributes, right-click the net/interface and click Clear Debug.