Performance metrics vary from design to design, and the best results are achieved if you follow the Hierarchical Design techniques suggested in Hierarchical Design Flows. You can find additional design recommendations in the UltraFast Design Methodology Guide for FPGAs and SoCs (UG949).
However, the additional restrictions that are required for silicon isolation are expected to have an impact on most designs. The application of partial reconfiguration rules, such as routing containment, exclusive placement, and no optimization across RM boundaries, means that the overall density and performance is lower for a DFX design than for the equivalent flat design. The overall design performance for DFX designs varies from design to design, based on factors such as the number of RPs, the number of interface pins to these partitions, and the size and shape of Pblocks.
Any potential Dynamic Function eXchange design must have extra timing slack and resource overhead before considering this solution. See the Building Up Implementation Requirements section for more information on evaluating a design for DFX.